If you need to connect Perl (ugh!) to Vsphere, with a Nagios Perl plugin for example, you’ll need the VMware VI Perl Tools SDK. It’s a .tar.gz (be sure to download the x86_64 unless you’re still on 32 bit architecture, but then you’ll have different priorities I guess). Unpack it, and, if you’re on Debian, open the vmware-install.pl file and change “ubuntu” to “debian” (don’t say anything).
Should work well. At least, it does for me, YMMV.